Metronomic chemotherapie & boosting the immuumsystem!

Estrogen can cause the growth of breast cancer cells. Hormone therapy using exemestane (aromasin) may fight breast cancer by blocking the use of estrogen by the tumor cells. Low dose cyclophosphamide (endoxan) may also stimulate the white blood cells, including natural killer cells, for instance by decreasing the suppressor (regulatory) T-cells. Giving exemestane (aromasin)  with cyclophosphamide may be an effective treatment for estrogen receptor-positive, progesterone receptor-positive, and HER2-negative stage IV

Bron en voor  meer info:
http://www.clinicalconnection.com/exp/EPVS.aspx?studyID=361737&slID=15645489

2. Rol Endoxan
 (in Nederland slechts op recept via het ziekenhuis te verkrijgen ALS DE ONCOLOOG dit wilt/kan voorschrijven --- problematisch dus ... ).

Using chemo-drugs or irradiation to breakdance immune tolerance and facilitate immunotherapy in solid cancer.

Zheng Y1, Dou Y1, Duan L1, Cong C1, Gao A1, Lai Q1, Sun Y2.

Author information

1Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.2Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China. Electronic address: sunyuping@live.cn.

Abstract

The immunity is dual host-protective and tumor-promoting in cancer development and progression. Many immune suppressive cells and cytokines in microenvironment can prevent cytotoxic T lymphocytes (CTL) and natural killer cells (NK) from killing tumor cells. Chemotherapy drugs and irradiation have been reported helpful in breaking immune tolerance and creating microenvironment for adoptive cell therapy. Low-dose cyclophosphamide or gemcitabine therapy can selectively deplete T regulatory cells (Treg). Paclitaxel can alter cytokine network at the tumor site, and 5-fluorouracil shows a pronounced effect on myeloid-derived suppressor cells (MDSC) depletion. Local tumor irradiation and total body irradiation (TBI) can also affect tumor microenvironment and facilitate immunotherapy. In this review, we summarize the particular effects of these agents and methods on immunomodulation, as well as their potential values in immunotherapy. The combination with immunotherapy represents a novel therapeutic strategy.Copyright © 2015 Elsevier Inc. All rights

We kunnen nog een hoop van China leren (dr Migeod chefarts Biomed kliniek)  gaat met regelmatig naar China om zijn vakkennis te updaten.

Maar ook in Amerika (The Issels foundation in Santa Barbara)is al veel verder te zijn dan het UMC+)  :

Voor meer informatie:
http://issels.com/cytokinesLAK.aspx#sthash.cWna70Bs.SfH21KAV.dpbs

Dit instituut schijnt erg goed, maar ook erg duur te zijn en waarschijnlijk voor slechts weinigen van ons financieel haalbaar.

Nk celltherapy
Stemcelltherapy
Etc.

Duitsland Helioskliniek Wiesbaden biedt ook stamcell therapie aan.
Dendric cell therapie wordt ook vaak aanbevolen maar kan pas geruime tijd na
Chemotherapie. Voor info over dendric celltherapy zie The Issels foundation.


© kanker gezond(er) benaderen 2015.