Milk Thistle National Cancer Institute

Bron http://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq


Do not use this with following medicine

• Statines (Altoco of Mecavor)
• Anxiolytica (Valium, Xanax of Ativan)
• Anticoagulantia (Coumadin of Plavix)
• Fenytoïne (Dilantin)
• Fexofenadine (Allegra)
• Antipsychotica (Chloorpromazine, Haloperidol, Promethazine of Flufenazine)

This complementary and alternative medicine (CAM) information summary provides an overview of the use of milk thistle as a treatment and adjunct agent for people with cancer.

The summary includes a brief history of milk thistle, a review of thelaboratory studies and clinical trials, and a description of adverse effectsassociated with milk thistle use.

This summary contains the following key information:

• Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver(!!) and biliary disorders.
• The active substance in milk thistle, silymarin, is a complex mixture of flavonolignans. Silymarin's primary constituents are the flavonolignan isomers silybins A and B, isosilybin A and B, silychristin (also known as silichristin), silydianin (also known as silidianin), and their flavonoid precursor, taxifolin. In the literature, the mixture of the silybins A and B is often referred to as silibinin.
• Laboratory studies demonstrate that silymarin stabilizes cellularmembranes, stimulates detoxification pathways, stimulates regeneration of liver tissue, inhibits the growth of certain cancer cell lines, exerts directcytotoxic activity toward certain cancer cell lines, and possibly increases the efficacy of certain chemotherapy agents.
• Human clinical trials have investigated milk thistle or silymarin primarily in individuals with hepatitis or cirrhosis, although small studies have been reported about individuals with acute lymphoblastic leukemia, prostate cancer, breast cancer, andhepatocellular carcinoma.
• Few adverse side effects have been reported for milk thistle, but little information about interactions with anticancer medications or other drugs is available.
• Milk thistle is available in the United States as a dietary supplement

http://www.optimalegezondheid.com/de-voor-en-nadelen-van-milk-thistle-mariadistel/
(translate in English and or check website national cancer institute to see side effects/dose/etc...!!)